By Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann
Detailing the most recent protocols for studying animal versions of diabetes, in particular resistant teams of rodents corresponding to the NOD mouse, and together with professional recommendation on implementation, it is a priceless new quantity within the equipment in Molecular Biology sequence.
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Interestingly, the rat colony has a higher frequency of diabetes incidence and the Hans-Georg Joost et al. ), Animal Models in Diabetes Research, Methods in Molecular Biology, vol. 1007/978-1-62703-068-7_3, © Springer Science+Business Media, LLC 2012 31 32 R. Bortell and C. Yang animals develop disease at an earlier age when they are housed in viral antibody-free (VAF) vivaria (1). As with humans, certain major histocompatibility complex (MHC) genes of rats have been shown to be critical for autoimmune risk.
Autoimmunity 33:199–211 29. Gold DP, Bellgrau D (1991) Identification of a limited T-cell receptor beta chain variable region repertoire associated with diabetes in the BB rat. Proc Natl Acad Sci U S A 88: 9888–9891 30. Sommandas V, Rutledge EA, Van Yserloo B et al (2005) Aberrancies in the differentiation and maturation of dendritic cells from bonemarrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat. J Autoimmun 25:1–12 31. Sommandas V, Rutledge EA, Van Yserloo B et al (2005) Defects in differentiation of bonemarrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.
Moreover, male Akita mice on C57BL/6 background developed more severe albuminuria, mesangial expansion, and renal and glomerular hypertrophy than the male mice with STZ-induced diabetes. These studies comparing both models on the same genetic background suggest that the Akita model offers advantages over chemical models of diabetes and thus, it may provide a better experimental platform for DN model development. 2. Impact of Genetic Background on Diabetic Kidney Injury in Akita Mice In humans with diabetes, it is well established that there is a clearcut genetic susceptibility to the development of kidney injury (12).
Animal Models in Diabetes Research by Hans-Georg Joost, Hadi Al-Hasani, Annette Schürmann