John S. Bradley MD, John D. Nelson MD Emeritus's 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial PDF

By John S. Bradley MD, John D. Nelson MD Emeritus

ISBN-10: 1581104294

ISBN-13: 9781581104295

This best-selling and regularly occurring source on pediatric antimicrobial remedy presents fast entry to trustworthy, up to the moment techniques for therapy of all infectious illnesses in young children. for every sickness, the authors offer a observation to assist overall healthiness care companies opt for the simplest of all antimicrobial offerings. Drug descriptions hide all antimicrobial brokers on hand this present day and contain entire information regarding dosing regimens. in line with starting to be issues approximately overuse of antibiotics, this system comprises guidance on while to not prescribe antimicrobials. Key beneficial properties: designed if you look after kids and are confronted with judgements on a daily basis; comprises therapy of parasitic infections and tropical medication; up to date anti-infective drug directory, entire with formulations and dosages; and balanced info on safeguard, efficacy, and tolerability with information on expenses and availability of drugs.

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Gonococcal arthritis or Ceftriaxone 50 mg/kg IV, IM q24h (BII); OR (if susceptible) PO cefixime 8 mg/kg/day (CII) as a single daily dose for tenosynovitis41,42 penicillin G 100,000 U/kg/day IV div q6h (AII); x 7 d penicillin-resistant strains. Quinolone resistance is increasing. – Infants (S aureus, including Empiric therapy: clindamycin (to cover CA-MRSA). For Oral therapy options: CA-MRSA; group A serious infections, ADD cefazolin to provide better For CA-MRSA: clindamycin OR linezolid40 streptococcus; Kingella MSSA coverage and add Kingella coverage For MSSA: cephalexin OR dicloxacillin kingae; in unimmunized or For CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or For Kingella, most penicillins or cephalosporins (but not immune-compromised vancomycin 40 mg/kg/day IV q8h clindamycin) children: pneumococcus, For MSSA: oxacillin 150 mg/kg/day IV div q6h OR H influenzae type b) cefazolin 100 mg/kg/day IV div q8h Total therapy (IV plus PO) for 3 wks with normal ESR; – Children (S aureus, including For Kingella: cefazolin, ampicillin, or ceftriaxone 50 mg/ low-risk, non-hip arthritis may respond to a 10-day CA-MRSA; group A kg/day IV, IM q24h course.

CIII) For CA-MRSA: clindamycin or linezolid (CIII) Watch for beta-lactam–associated neutropenia with high-dose, long-term therapy, and neutropenia/ thrombocytopenia with long-term linezolid – Acute, other organisms – Infants and children, acute Empiric therapy: clindamycin. For serious infections, In children with open fractures secondary to trauma, add infection (usually S aureus, ADD cefazolin to provide better MSSA coverage and ceftazidime for extended aerobic gram-negative activity including CA-MRSA; group add Kingella coverage (CIII) Kingella is often resistant to clindamycin A streptococcus; K kingae) For CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or For MSSA (BI) and Kingella (BIII), follow-up oral therapy vancomycin 40 mg/kg/day IV q8h (BII) with cephalexin 100 mg/kg/day PO div tid For MSSA: oxacillin 150 mg/kg/day IV div q6h OR Oral therapy alternatives for CA-MRSA include cefazolin 100 mg/kg/day IV div q8h (AII) clindamycin and linezolid40 For Kingella: cefazolin, ampicillin or ceftriaxone 50 mg/kg/day IV, IM q24h (BIII) Total therapy (IV plus PO) for 4–6 wks for MSSA.

Consult the index for the alphabetized listing of diseases and Chapters 7 through 10 for the alphabetized listing of pathogens and for uncommon organisms not included in this chapter. • Abbreviations: ADH, antidiuretic hormone; AFB, acid-fast bacilli; amox/clav, amoxicillin/clavulanate; amp/sulbactam, ampicillin/ sulbactam; bid, twice daily; AOM, acute otitis media; CA-MRSA, community-associated methicillin-resistant Staphylococcus aureus; CMV, cytomegalovirus; CNS, central nervous system; CSF, cerebrospinal fluid; CT, computed tomography; div, divided; EBV, Epstein-Barr virus; ESBL, extended spectrum beta-lactamase; ESR, erythrocyte sedimentation rate; FDA, US Food and Drug Administration; HAP/VAP, hospital-acquired pneumonia/ventilator-acquired pneumonia; HIV, human immunodeficiency virus; HSV, herpes simplex virus; HUS, hemolytic uremic syndrome; I&D, incision and drainage; IM, intramuscular; inh, inhaled; IV, intravenous; IVIG, intravenous immune globulin; LP, lumbar puncture; MAC, Mycobacterium avium complex; MSSA, methicillin-susceptible S aureus; MSSE, methicillin-sensitive Staphylococcus epidermidis; MRSE, methicillin-resistant S epidermidis; ophth, ophthalmic; pen-R, penicillin-resistant; pen-S, penicillin-susceptible; pip/tazo, piperacillin/tazobactam; PO, orally; PPD, purified protein derivative; qd, once daily; qid, 4 times daily; RSV, respiratory syncytial virus; SPAG-2, small particle aerosol generator-2; STI, sexually transmitted infection; soln, solution; ticar/clav, ticarcillin/clavulanate; tid, 3 times daily; TB, tuberculosis; TMP/SMX, trimethoprim/ sulfamethoxazole; VDRL, Venereal Disease Research Laboratories; WBC, white blood cell.

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2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy by John S. Bradley MD, John D. Nelson MD Emeritus

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